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Pyridoxal 5′-phosphate (PLP)-dependent enzymes catalyse a diverse range of chemical transformations. Despite their extraordinary functional diversity, no PLP-dependent enzyme is known to.

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Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy - PMC Journal List Arch Dis Child v.90 (5); 2005 May PMC1720393 As a library, NLM provides access to scientific literature.

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Piridoksal-5′-fosfat (PLP, P-5-P), B6 vitamininin aktif bir şeklidir. Bu vitamin her yönüyle, vücuttaki amino asitlerin, karbonhidratların ve lipitlerin metabolizmasını sağlamaktadır. Bağışıklık sistemini desteklemek, kan şekeri kontrolü, hemoglobin oluşturma, antioksidan korumanın arttırılması gibi faydaları bulunmaktadır.

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Pyridoxal phosphate (P-5-P or PLP) is an active form of vitamin B6, a nutrient that supports the immune system, heart and brain health, blood sugar control, and more. P-5-P drives the activity of over 100 enzymes and helps make key neurotransmitters in the brain.

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Pyridoxal 5'-phosphate (PLP) acts as cofactor for over 150 enzymes (1, 2) involved in a number of metabolic pathways such as the synthesis, transformation, and degradation of amines and amino acids; supply of one carbon units; transsulfuration; synthesis of tetrapyrrolic compounds (including heme) and polyamines; and biosynthesis and degradation of neurotransmitters.

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Covering: up to March 2019 Amino acid racemases and epimerases are key enzymes that invert the configuration of common amino acids and supply many corresponding d-isomers in living organisms. Some d-amino acids are inherently bioactive, whereas others are building blocks for important biomolecules,.

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Pyridoxal 5'-phosphate is the monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal. It has a role as a coenzyme, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a mouse metabolite, an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor and a cofactor.

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Dalam metabolismenya, vitamin B6 akan dikonversi menjadi piridoksal-5-fosfat yang berfungsi sebagai koenzim dalam sintesis asam amino, neurotransmitter, sfingolipid, dan asam aminolevulinat. [1,2,5] Farmakodinamik Vitamin B6 dikonversikan menjadi piridoksal fosfat dan piridoksamin fosfat di dalam sel darah merah.

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Pyridoxal 5′-phosphate (PLP) is the cofactor involved in the stabilization of carbanions at Cα of amino acids and plays a key role in amino acid metabolism. In each case, PLP is covalently bound to its cognate enzyme by an imine with the amino group of lysine. Two de novo pathways for the biosynthesis of PLP are shown in Scheme 7.

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Vitamin B6 is an essential metabolite in all organisms. De novo synthesis of the vitamin can occur through either of two mutually exclusive pathways referred to as deoxyxylulose 5-phosphate-dependent and deoxyxylulose 5-phosphate-independent. The latter pathway has only recently been discovered and is distinguished by the presence of two genes, Pdx1 and Pdx2, encoding the synthase and.

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Pyridoxal phosphate, otherwise known as pyridoxal 5 phosphate, is the active form of vitamin B and a coenzyme in a variety of enzymatic reactions. PLP, as it is sometimes referred to as in science circles, is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain.

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Piridoksal-fosfat (PLP, piridoksal -5'- fosfat, P5P) je prostetska grupa više enzima. On je aktivna forma vitamina B 6, koji se sastoji od tri prirodna organska jedinjenja, piridoksal, piridoksamin i piridoksin . Uloga PLP deluje kao koenzim u reakcijama transaminacije, kao i u nekim od reakcija dekarboksilacije i deaminacije aminokiselina.

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Pyridoxal phosphate is a cofactor of aromatic L-amino acids decarboxylase. This allows for conversion of 5-hydroxytryptophan (5-HTP) into serotonine (5-HT). This reaction takes place in serotonergic neurons. Metabolism and biosynthesis of histamine. Pyridoxal phosphate is a cofactor of L-histidine decarboxylase.

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91971770. Structure. Molecular Formula. C8H10NO6P. Synonyms. Pyridoxal 5-Phosphate Hydrate. Molecular Weight. 250.16 g/mol. Computed by PubChem 2.1 (PubChem release 2021.05.07)

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Aktivni oblik vitamina B 6 je piridoksal 5'-fosfat .. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer.